Polymorphism in immunoglobulin heavy chains suggesting gene conversion.
نویسندگان
چکیده
منابع مشابه
Distribution of immunoglobulin heavy chains in diseased synovia.
Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting for mu heavy chains.
متن کاملInherent Anti-amyloidogenic Activity of Human Immunoglobulin Heavy Chains*
Sharad P. Adekar, Igor Klyubin, Sally Macy, Michael J. Rowan, Alan Solomon, Scott K. Dessain, and Brian O’Nuallain From the Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, the Trinity College Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland, and the Human Immunology and Cancer Program, Department of Medicine, U...
متن کاملRichter's syndrome with different immunoglobulin light chains and different heavy chain gene rearrangements.
In a patient with Richter's syndrome, the chronic lymphocytic leukemia (CLL) expressed lambda, mu, and delta immunoglobulin (lg) chains and the non-Hodgkin lymphoma (NHL) kappa, mu, and delta lg chains. The difference in lg light chain expression suggests that the CLL and NHL are independent malignancies, or that the oncogenic event occurred in a B cell differentiation stage after the heavy cha...
متن کاملChromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains
To determine the chromosomal location of mouse immunoglobulin heavy chain structural genes unambiguously, a panel of somatic cell hybrids was scored for the presence of DNA sequences homologous to gamma 2b-, mu-, and alpha-heavy chain-constant region DNA probe molecules. The hybrids, formed between mouse and hamster cells, contained various combinations of mouse chromosomes plus a full set of h...
متن کاملChromosomal location of the genes for human immunoglobulin heavy chains.
We have studied somatic cell hybrids between P3x63Ag8 mouse myeloma cells deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and either human peripheral lymphocytes or human lymphoblastoid or myeloma cells for the production of human immunoglobulin chains and for the expression of enzyme markers assigned to each of the different human chromosomes. Human chromosome 14 was the only ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1982
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.79.10.3280